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5-Amino-1MQ

Präklinisch

NNMT Inhibitor | Longevity & Metabolic Enhancement

LanglebigkeitMetabolischGewichtsverlust

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function.

Molekulare und Forschungsdaten

Halbwertszeit
4-7 hours (3.8h IV, 6.9h oral)
Wege (Forschung)
oral, injectable
Lagerung
Oral: room temp. Injectable: lyophilized room temp or freezer, reconstituted 2-8°C for 28 days

Overview

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols.

Mechanism of action

Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.

Key research findings

  • Enhanced NAD+ levels
  • Improved mitochondrial function
  • Better energy metabolism
  • Enhanced cellular repair
  • Improved insulin sensitivity
  • Longevity support
  • Convenient daily oral dosing

Research applications

Longevity

  • NAD+ Enhancement — Significantly increases cellular NAD+ levels by inhibiting NNMT enzyme, supporting cellular energy production and DNA repair mechanisms essential for healthy aging.
  • Mitochondrial Function — Improves mitochondrial biogenesis and efficiency, enhancing cellular energy production and reducing oxidative stress markers associated with aging.
  • Cellular Repair — Enhanced NAD+ availability supports sirtuins and other longevity pathways involved in DNA repair, cellular maintenance, and stress resistance.

Metabolism

  • Energy Metabolism — Improvement through enhanced mitochondrial efficiency.
  • Insulin Sensitivity — Enhancement via cellular energy optimization.
  • Metabolic Flexibility — Improved glucose/fat substrate switching.

Weight Loss

  • Metabolic Rate Enhancement — Supports increased basal metabolic rate.
  • Fat Oxidation — Improvements in fat burning capacity.

5-Amino-1MQ Häufig gestellte Fragen

What is the difference between the mcg and mg protocols for 5-Amino-1MQ injection?+

Two vastly different dosing protocols exist differing by 100-200x: the mcg protocol uses 150-500mcg daily while the mg protocol uses ~350mg (5mg/kg) daily. This massive discrepancy creates serious overdose risk. Always verify units (mcg vs mg) before reconstitution to avoid a potentially 100+ fold dosing error.

Does 5-Amino-1MQ actually increase NAD+ levels in humans?+

Animal studies demonstrate significant NAD+ elevation through NNMT inhibition. A 2024 study showed aged mice treated with 5A1MQ gained ~40% greater grip strength vs controls, with improved intramuscular lipid content and muscle fiber cross-sectional area, providing evidence that NAD+ enhancement translates to functional improvements.

Can I take 5-Amino-1MQ with food or does it need to be on an empty stomach?+

Take 5-Amino-1MQ with food to improve absorption and reduce potential GI effects. Consistent daily timing helps maintain steady NAD+ levels, and morning or early afternoon dosing is preferred to avoid potential sleep interference.

What's the timeline for seeing metabolic benefits from 5-Amino-1MQ?+

Week 1-2 shows gradual energy increase and mental clarity. Week 2-4 brings enhanced exercise performance and recovery. Week 4-8 shows improved metabolic markers and body composition changes. Peak longevity benefits with sustained cellular health improvements appear by week 8-12 with continuous use.

References

  1. [1]Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in miceBiochemical Pharmacology
  2. [2]Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studiesJournal of Pharmaceutical and Biomedical Analysis
  3. [3]Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged miceScientific Reports
  4. [4]Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctionBiochemical Pharmacology
  5. [5]Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopeniaAging Cell

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