Cortagen

Overview

Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia’s St. Petersburg Institute of Bioregulation and Gerontology, it regulates inflammatory responses in the nervous system, restores balance between pro- and anti-oxidative processes, and stimulates interleukin-2 expression. Research shows potential benefits for ischemic brain injury recovery, nerve regeneration, and reducing autoimmune reactions affecting the CNS.

Mechanism of action

Cortagen works through epigenetic regulation by penetrating cell nuclei and interacting with DNA to modulate gene expression. In the heart, it affects genes including Pass1, Hsc70, Bmp2, Wnt4, Eps15, and Eps15-rs. It powerfully regulates inflammatory responses in the nervous system, helping restore proper balance between oxidative and anti-oxidative processes. Cortagen stimulates IL-2 expression and helps regulate immune function, particularly by reducing autoimmune reactions.

Key research findings

• Regulates central nervous system function
• Powerful anti-inflammatory effects in brain
• Supports nerve regeneration
• Restores oxidative balance
• Stimulates interleukin-2 expression
• Reduces autoimmune reactions
• Beneficial after ischemic brain injury
• Modulates gene expression in neural tissue

Research applications

Neurological Support

• Ischemic Brain Injury Recovery — Shows beneficial long-term results in research following ischemic brain injury.
• Nerve Regeneration — Research demonstrates effects on restoration of injured nerve function.
• Neuroinflammation — Regulates inflammatory response in the nervous system.

Immune Regulation

• Autoimmune Modulation — Helps regulate immune function by reducing autoimmune reactions.
• IL-2 Stimulation — Stimulates interleukin-2 expression for immune regulation.

Anti-Aging

• Oxidative Balance — Restores balance between pro- and anti-oxidative processes.
• Brain Aging — Addresses age-related CNS changes through bioregulation.