Selank
Bien estudiadoAnxiolytic & Nootropic Peptide | Tuftsin Analog
Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences.
Datos moleculares y de investigación
- Secuencia
- Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Peso molecular
- 751.89 Da
- Vida media
- 2-10 minutes
- Objetivos primarios
- bdnf, dopamine-receptor, gaba, serotonin-receptor
- Rutas (investigación)
- injectable, nasal
- Almacenamiento
- Reconstituted: 2-8°C, use within 30 days
Overview
Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences. It provides anxiolytic effects comparable to benzodiazepines but without sedation, amnesia, tolerance, or withdrawal.
Mechanism of action
Works through allosteric modulation of GABA-A receptors, serotonin and dopamine system optimization, enkephalin degradation inhibition, IL-6 and cytokine balance regulation, and BDNF upregulation in the hippocampus.
Key research findings
- Rapid onset anxiolytic effects
- Enhanced BDNF expression (30% increase)
- Improved stress resilience
- Cognitive enhancement
- Immune modulation
- No tolerance or withdrawal
- Neuroprotective effects
Research applications
Anxiety
- Generalized Anxiety Disorder — Clinical trials show significant reduction in anxiety symptoms comparable to benzodiazepines but without sedation or amnesia.
- Post-Traumatic Stress Disorder — Research indicates effectiveness in PTSD treatment.
- Social Anxiety — Reduces anticipatory anxiety and performance stress.
Cognitive
- Memory Enhancement — Improves memory consolidation and learning capacity.
- Attention and Focus — Enhanced sustained attention during demanding cognitive tasks.
- Neuroprotection — BDNF upregulation supports long-term brain health.
Immune
- Immune Modulation — Balances immune system function through cytokine regulation.
- Antiviral Activity — Shows activity against influenza, HSV, and cytomegalovirus.
- Inflammation Regulation — Modulates inflammatory gene expression.
Preguntas frecuentes sobre Selank
Can Selank be taken long-term without losing effectiveness, or will I build tolerance?+
Selank avoids the tolerance and dependence issues of benzodiazepines, but the file specifically recommends limiting cycles to 2-3 weeks with breaks between them. This suggests potential GABAergic desensitization is possible with continuous use, though not true pharmacological tolerance. Cycling prevents this.
Is intranasal Selank as effective as injection for anxiety?+
Yes, potentially more so. Intranasal offers fastest onset (15-30 minutes) with 4-6 hour duration, while injection takes 30-60 minutes but may last longer. Both are effective—choose based on how quickly you need relief. Nasal is better for as-needed anxiety; injection is better for daily protocols.
Will Selank help with PTSD, or is it just for generalized anxiety?+
Selank is documented to help PTSD. Research shows effectiveness in PTSD treatment (rated as 'effective'). It modulates stress response through multiple systems (GABA, serotonin, dopamine, BDNF), which addresses trauma-related dysregulation. However, it's typically used alongside proper PTSD therapy, not as sole treatment.
How does Selank's 30% BDNF increase compare to other nootropics?+
It's significant. A 30% increase in hippocampal BDNF supports neuroplasticity and long-term potentiation (learning/memory). Semax shows similar effects. Compounds like noopept also increase BDNF, but through different pathways. Selank's unique value is anxiety relief plus BDNF elevation without sedation—a rare combination.
References
- [1]Selank Administration Affects the Expression of Some Genes Involved in GABAergic NeurotransmissionFrontiers in Pharmacology
- [2]Efficacy and Possible Mechanisms of Action of a New Peptide Anxiolytic Selank in the Therapy of Generalized Anxiety Disorders and NeurastheniaZhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- [3]Intranasal Administration of the Peptide Selank Regulates BDNF Expression in the Rat Hippocampus In VivoDoklady Biological Sciences
- [4]Experimental Optimization of Learning and Memory Processes by SelankEksperimental'naia i Klinicheskaia Farmakologiia
- [5]A Comparison of the Anxiolytic Effect and Tolerability of Selank and Phenazepam in the Treatment of Anxiety DisordersZhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- [6]The Influence of Selank on the Level of Cytokines Under the Conditions of Social StressBulletin of Experimental Biology and Medicine
- [7]Selank Protects Against Ethanol-Induced Memory Impairment by Regulating BDNF ContentBulletin of Experimental Biology and Medicine
- [8]Antiviral Activity of Immunomodulator Selank in Experimental Influenza InfectionVoprosy Virusologii
- [9]Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological ActivityProtein & Peptide Letters
Péptidos relacionados
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NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics.
Adalank
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Enhanced derivative of Selank with improved stability, blood-brain barrier penetration, and extended half-life compared to parent compound. Parent compound Selank approved in Russia since early 2000s.
Adamax
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