PeptideDB

Longevity peptides

Longevity peptides include mitochondrial-derived peptides (MDPs), NAD+-pathway modulators, and bioregulators. Research focuses on mitochondrial biogenesis, cellular stress resistance, and metabolic flexibility as proposed levers on healthspan.

5-Amino-1MQ

Preclinical

NNMT Inhibitor | Longevity & Metabolic Enhancement

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function.

LongevityMetabolicWeight Loss

Adalank

Emerging research

N-Acetyl Selank Amidate | Enhanced Tuftsin Analog

Enhanced derivative of Selank with improved stability, blood-brain barrier penetration, and extended half-life compared to parent compound. Parent compound Selank approved in Russia since early 2000s.

CognitiveLongevity

Adamax

Emerging research

Next-Generation Semax Derivative | Nootropic Neuropeptide

Synthetic nootropic peptide with N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration, researched for cognitive enhancement,

CognitiveLongevity

Cardiogen

Moderate research

AEDR | Cardiovascular Bioregulator Peptide

Cardiogen is a Khavinson bioregulator peptide consisting of four amino acids, derived from heart tissue research.

LongevityRecovery & Healing

Cartalax

Emerging research

Bioregulatory Tripeptide | Cartilage & Connective Tissue Support

Synthetic tripeptide developed by Professor Vladimir Khavinson, supporting cartilage, connective tissue, and cellular regeneration through proliferation markers and apoptosis pathway modulation.

Recovery & HealingLongevity

Cerebrolysin

Well studied

Neuropeptide Preparation | Neurological Recovery

Standardized neuropeptide preparation containing bioactive peptides and amino acids exhibiting neurotrophic and neuroprotective properties for stroke recovery, traumatic brain injury, and cognitive

CognitiveLongevity

Chonluten

Moderate research

EDG Tripeptide | Bronchial/Lung Bioregulator

Chonluten is a Khavinson bioregulator tripeptide (EDG) derived from respiratory lung tissue. Developed at Russia's St.

ImmuneLongevity

Cortagen

Moderate research

AEDP | Brain Cortex Bioregulator Peptide

Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St.

CognitiveLongevity

Crystagen

Moderate research

EDP Tripeptide | Thymus Immune Bioregulator

Crystagen is a Khavinson bioregulator tripeptide (EDP) identified in thymalin with selective action on thymus tissues. Developed at Russia's St.

ImmuneLongevity

Cyclic Glycine-Proline

Moderate research

IGF-1 Bioavailability Regulator & Neuroprotective Peptide

Endogenous cyclic dipeptide found in plasma, breast milk, and cerebrospinal fluid. Functions as metabolite of IGF-1, regulating its bioavailability through competitive binding to IGFBP-3.

CognitiveLongevity

Dihexa

Emerging research

Synaptogenic Peptide | Cognitive Enhancement

Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis.

CognitiveLongevity

Epitalon

Preclinical

Tetrapeptide studied for telomere & pineal effects

Epitalon is a synthetic tetrapeptide derived from the pineal peptide epithalamin, studied primarily in Russian research for proposed effects on telomerase activity, circadian regulation, and ageing.

Longevity

FOXO4-DRI

Emerging research

Senolytic Peptide | p53-FOXO4 Disruptor

FOXO4-DRI is a senolytic peptide designed to selectively eliminate senescent 'zombie' cells that accumulate with age and contribute to tissue dysfunction.

Longevity

Glutathione

Extensively studied

L-Glutathione | Master Antioxidant Tripeptide

Glutathione is the body's master antioxidant, a tripeptide produced naturally by the liver.

LongevityImmune

Humanin

Moderate research

Mitochondria-Derived Peptide | HN

Humanin was the first mitochondria-derived peptide (MDP) discovered, originally cloned from the occipital lobe of an Alzheimer's patient.

LongevityCognitive

Livagen

Moderate research

KEDA Tetrapeptide | Liver Bioregulator

Livagen is a Khavinson bioregulator tetrapeptide (KEDA) with significant hepatoprotective and immunomodulatory properties.

LongevityImmune

MOTS-c

Preclinical

Mitochondrial-derived peptide studied for metabolism

MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial DNA, studied in animal models for its role in metabolic regulation, insulin sensitivity, and exercise-like adaptations.

LongevityWeight Loss

NA Semax Amidate

Well studied

Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection

Enhanced and stabilized version of Russian nootropic Semax with superior stability, extended half-life, and enhanced bioavailability through acetylation and amidation modifications.

CognitiveLongevity

NA-Selank Amidate

Moderate research

N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic

NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics.

CognitiveLongevityImmune

NAD+

Extensively studied

Essential Cellular Coenzyme & Anti-Aging Therapy

NAD+ is a crucial coenzyme found in every cell, involved in energy generation and cellular maintenance that naturally declines with age.

LongevityMetabolic

Ovagen

Moderate research

EDL Tripeptide | Liver & GI Bioregulator

Ovagen is a Khavinson bioregulator tripeptide (EDL) with primary effects on the liver and gastrointestinal tract. Developed by Dr. Vladimir Khavinson at the St.

Longevity

P21

Emerging research

P021 | CNTF-Derived Neurogenic Peptide

P21 is a nootropic peptide derived from ciliary neurotrophic factor (CNTF) that enhances neurogenesis and cognitive function.

CognitiveLongevity

Pancragen

Moderate research

KEDW Tetrapeptide | Pancreas Bioregulator

Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St.

LongevityMetabolic

PE-22-28

Emerging research

TREK-1 Channel Blocker | Shortened Spadin Analog

Synthetic heptapeptide derived from Spadin positions 22-28, functioning as potent TREK-1 antagonist with enhanced selectivity and duration versus parent compound.

CognitiveLongevity

Pinealon

Well studied

Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement

Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement.

CognitiveSleepLongevity

PNC-27

Emerging research

Anti-Cancer Peptide | p53-HDM-2 Disruptor

PNC-27 is an experimental anti-cancer peptide created by a supercomputer at SUNY Downstate Medical Center in 2000.

Longevity

Selank

Well studied

Anxiolytic & Nootropic Peptide | Tuftsin Analog

Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences.

CognitiveLongevityImmune

Semax

Well studied

Synthetic ACTH Analog | Nootropic & Neuroprotective Peptide

Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, originally developed in Russia for stroke recovery.

CognitiveLongevity

SLU-PP-332

Emerging research

Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator

Groundbreaking synthetic compound from Saint Louis University functioning as pan-estrogen-related receptor agonist with preferential ERRα activity.

MetabolicLongevity

SS-31

Well studied

Mitochondrial-Targeted Peptide | Cardiolipin Protector

SS-31 (Elamipretide) is an aromatic-cationic tetrapeptide that selectively binds to cardiolipin in the inner mitochondrial membrane, preventing lipid peroxidation and optimizing electron transport

LongevityMetabolic

TB-500 (Ac-LKKTETQ)

Moderate research

Thymosin Beta-4 Active Fragment | Healing Peptide

TB-500 (Ac-LKKTETQ) is a synthetic derivative of thymosin beta-4 consisting of the N-terminal acetylated 17-23 amino acid fragment.

Recovery & HealingLongevity

Testagen

Moderate research

KEDG Tetrapeptide | Testicular Bioregulator

Testagen is a Khavinson bioregulator tetrapeptide (KEDG) originally isolated from testicular tissue extracts. Developed by Professor Vladimir Khavinson at the St.

Sexual HealthLongevity

Thymalin

Well studied

Thymic Peptide Bioregulator | Immune Modulator

Thymalin is a natural peptide bioregulator derived from calf thymus gland, developed in the Soviet Union in the 1970s.

ImmuneLongevity

Thymogen

Well studied

EW Dipeptide | Thymus Immune Bioregulator

Thymogen (EW dipeptide) is a Khavinson bioregulator consisting of glutamic acid and tryptophan, originally isolated from calf thymus extracts (Thymalin) in the late 1980s.

ImmuneLongevity

Thymulin

Well studied

FTS | Zinc-Dependent Thymic Nonapeptide

Thymulin is a nonapeptide hormone exclusively secreted by thymic epithelial cells, discovered by Jean-François Bach in the 1970s.

ImmuneLongevity

Vesilute

Moderate research

ED Dipeptide | Bladder & Urinary Tract Bioregulator

Vesilute is a Khavinson bioregulator dipeptide consisting of glutamic acid and aspartic acid (ED), developed at the St. Petersburg Institute of Bioregulation and Gerontology.

OtherLongevity

Vesugen

Moderate research

KED | Vascular Bioregulator Peptide

Vesugen is a Khavinson bioregulator tripeptide developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology.

LongevityRecovery & Healing

Vilon

Moderate research

KE Dipeptide | Thymus Immune Bioregulator

Vilon is a Khavinson bioregulator dipeptide (KE) consisting of lysine and glutamic acid, originally isolated from thymus gland extracts. Developed by Professor Vladimir Khavinson at the St.

ImmuneLongevity

Wolverine Stack

Well studied

BPC-157 + TB-500 | Tissue Repair & Recovery Protocol

Combines BPC-157 and TB-500 for synergistic tissue repair and recovery. 87.5% improvement in knee pain patients per Lee & Padgett 2021 study.

Recovery & HealingLongevity