Longevity peptides
Longevity peptides include mitochondrial-derived peptides (MDPs), NAD+-pathway modulators, and bioregulators. Research focuses on mitochondrial biogenesis, cellular stress resistance, and metabolic flexibility as proposed levers on healthspan.
5-Amino-1MQ
PreclinicalNNMT Inhibitor | Longevity & Metabolic Enhancement
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function.
Adalank
Emerging researchN-Acetyl Selank Amidate | Enhanced Tuftsin Analog
Enhanced derivative of Selank with improved stability, blood-brain barrier penetration, and extended half-life compared to parent compound. Parent compound Selank approved in Russia since early 2000s.
Adamax
Emerging researchNext-Generation Semax Derivative | Nootropic Neuropeptide
Synthetic nootropic peptide with N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration, researched for cognitive enhancement,
Cardiogen
Moderate researchAEDR | Cardiovascular Bioregulator Peptide
Cardiogen is a Khavinson bioregulator peptide consisting of four amino acids, derived from heart tissue research.
Cartalax
Emerging researchBioregulatory Tripeptide | Cartilage & Connective Tissue Support
Synthetic tripeptide developed by Professor Vladimir Khavinson, supporting cartilage, connective tissue, and cellular regeneration through proliferation markers and apoptosis pathway modulation.
Cerebrolysin
Well studiedNeuropeptide Preparation | Neurological Recovery
Standardized neuropeptide preparation containing bioactive peptides and amino acids exhibiting neurotrophic and neuroprotective properties for stroke recovery, traumatic brain injury, and cognitive
Chonluten
Moderate researchEDG Tripeptide | Bronchial/Lung Bioregulator
Chonluten is a Khavinson bioregulator tripeptide (EDG) derived from respiratory lung tissue. Developed at Russia's St.
Cortagen
Moderate researchAEDP | Brain Cortex Bioregulator Peptide
Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St.
Crystagen
Moderate researchEDP Tripeptide | Thymus Immune Bioregulator
Crystagen is a Khavinson bioregulator tripeptide (EDP) identified in thymalin with selective action on thymus tissues. Developed at Russia's St.
Cyclic Glycine-Proline
Moderate researchIGF-1 Bioavailability Regulator & Neuroprotective Peptide
Endogenous cyclic dipeptide found in plasma, breast milk, and cerebrospinal fluid. Functions as metabolite of IGF-1, regulating its bioavailability through competitive binding to IGFBP-3.
Dihexa
Emerging researchSynaptogenic Peptide | Cognitive Enhancement
Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis.
Epitalon
PreclinicalTetrapeptide studied for telomere & pineal effects
Epitalon is a synthetic tetrapeptide derived from the pineal peptide epithalamin, studied primarily in Russian research for proposed effects on telomerase activity, circadian regulation, and ageing.
FOXO4-DRI
Emerging researchSenolytic Peptide | p53-FOXO4 Disruptor
FOXO4-DRI is a senolytic peptide designed to selectively eliminate senescent 'zombie' cells that accumulate with age and contribute to tissue dysfunction.
Glutathione
Extensively studiedL-Glutathione | Master Antioxidant Tripeptide
Glutathione is the body's master antioxidant, a tripeptide produced naturally by the liver.
Humanin
Moderate researchMitochondria-Derived Peptide | HN
Humanin was the first mitochondria-derived peptide (MDP) discovered, originally cloned from the occipital lobe of an Alzheimer's patient.
Livagen
Moderate researchKEDA Tetrapeptide | Liver Bioregulator
Livagen is a Khavinson bioregulator tetrapeptide (KEDA) with significant hepatoprotective and immunomodulatory properties.
MOTS-c
PreclinicalMitochondrial-derived peptide studied for metabolism
MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial DNA, studied in animal models for its role in metabolic regulation, insulin sensitivity, and exercise-like adaptations.
NA Semax Amidate
Well studiedEnhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection
Enhanced and stabilized version of Russian nootropic Semax with superior stability, extended half-life, and enhanced bioavailability through acetylation and amidation modifications.
NA-Selank Amidate
Moderate researchN-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic
NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics.
NAD+
Extensively studiedEssential Cellular Coenzyme & Anti-Aging Therapy
NAD+ is a crucial coenzyme found in every cell, involved in energy generation and cellular maintenance that naturally declines with age.
Ovagen
Moderate researchEDL Tripeptide | Liver & GI Bioregulator
Ovagen is a Khavinson bioregulator tripeptide (EDL) with primary effects on the liver and gastrointestinal tract. Developed by Dr. Vladimir Khavinson at the St.
P21
Emerging researchP021 | CNTF-Derived Neurogenic Peptide
P21 is a nootropic peptide derived from ciliary neurotrophic factor (CNTF) that enhances neurogenesis and cognitive function.
Pancragen
Moderate researchKEDW Tetrapeptide | Pancreas Bioregulator
Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St.
PE-22-28
Emerging researchTREK-1 Channel Blocker | Shortened Spadin Analog
Synthetic heptapeptide derived from Spadin positions 22-28, functioning as potent TREK-1 antagonist with enhanced selectivity and duration versus parent compound.
Pinealon
Well studiedSynthetic Tripeptide | Neuroprotection & Cognitive Enhancement
Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement.
PNC-27
Emerging researchAnti-Cancer Peptide | p53-HDM-2 Disruptor
PNC-27 is an experimental anti-cancer peptide created by a supercomputer at SUNY Downstate Medical Center in 2000.
Selank
Well studiedAnxiolytic & Nootropic Peptide | Tuftsin Analog
Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences.
Semax
Well studiedSynthetic ACTH Analog | Nootropic & Neuroprotective Peptide
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, originally developed in Russia for stroke recovery.
SLU-PP-332
Emerging researchSynthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator
Groundbreaking synthetic compound from Saint Louis University functioning as pan-estrogen-related receptor agonist with preferential ERRα activity.
SS-31
Well studiedMitochondrial-Targeted Peptide | Cardiolipin Protector
SS-31 (Elamipretide) is an aromatic-cationic tetrapeptide that selectively binds to cardiolipin in the inner mitochondrial membrane, preventing lipid peroxidation and optimizing electron transport
TB-500 (Ac-LKKTETQ)
Moderate researchThymosin Beta-4 Active Fragment | Healing Peptide
TB-500 (Ac-LKKTETQ) is a synthetic derivative of thymosin beta-4 consisting of the N-terminal acetylated 17-23 amino acid fragment.
Testagen
Moderate researchKEDG Tetrapeptide | Testicular Bioregulator
Testagen is a Khavinson bioregulator tetrapeptide (KEDG) originally isolated from testicular tissue extracts. Developed by Professor Vladimir Khavinson at the St.
Thymalin
Well studiedThymic Peptide Bioregulator | Immune Modulator
Thymalin is a natural peptide bioregulator derived from calf thymus gland, developed in the Soviet Union in the 1970s.
Thymogen
Well studiedEW Dipeptide | Thymus Immune Bioregulator
Thymogen (EW dipeptide) is a Khavinson bioregulator consisting of glutamic acid and tryptophan, originally isolated from calf thymus extracts (Thymalin) in the late 1980s.
Thymulin
Well studiedFTS | Zinc-Dependent Thymic Nonapeptide
Thymulin is a nonapeptide hormone exclusively secreted by thymic epithelial cells, discovered by Jean-François Bach in the 1970s.
Vesilute
Moderate researchED Dipeptide | Bladder & Urinary Tract Bioregulator
Vesilute is a Khavinson bioregulator dipeptide consisting of glutamic acid and aspartic acid (ED), developed at the St. Petersburg Institute of Bioregulation and Gerontology.
Vesugen
Moderate researchKED | Vascular Bioregulator Peptide
Vesugen is a Khavinson bioregulator tripeptide developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology.
Vilon
Moderate researchKE Dipeptide | Thymus Immune Bioregulator
Vilon is a Khavinson bioregulator dipeptide (KE) consisting of lysine and glutamic acid, originally isolated from thymus gland extracts. Developed by Professor Vladimir Khavinson at the St.
Wolverine Stack
Well studiedBPC-157 + TB-500 | Tissue Repair & Recovery Protocol
Combines BPC-157 and TB-500 for synergistic tissue repair and recovery. 87.5% improvement in knee pain patients per Lee & Padgett 2021 study.