CJC-1295 vs Ipamorelin
Not really rivals — a GHRH analog and a GHRP studied as a synergistic pair.
In short: CJC-1295 and Ipamorelin act on different receptors and are most often researched in combination rather than as alternatives.
Side-by-side comparison
| CJC-1295 | Ipamorelin | |
|---|---|---|
| Class / subtitle | Long-acting GHRH analog | Selective ghrelin-mimetic GHRP |
| Research status | In clinical trials | In clinical trials |
| Categories | Growth Hormone | Growth Hormone |
| Primary targets | GHRH receptor | GHS-R1a (ghrelin receptor) |
| Half-life | ≈6–8 days with DAC; ≈30 minutes without DAC (Mod GRF 1-29) | ≈2 hours |
| Sequence | Modified GRF(1-29) tetrasubstituted analog with a Drug Affinity Complex (DAC) linker | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Molecular formula | C152H252N44O42 | C38H49N9O5 |
| Molecular weight | ≈3647.2 g/mol (with DAC) | 711.85 g/mol |
| CAS number | 863288-34-0 | 170851-70-4 |
| Routes (research) | subcutaneous | subcutaneous |
CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH) engineered for a dramatically extended half-life, studied for its ability to raise growth hormone and IGF-1 levels.
Full CJC-1295 profileIpamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates GH release with minimal effect on cortisol, prolactin, or appetite, making it the cleanest of the classic GHRPs.
Full Ipamorelin profileFAQ
What is the main difference between CJC-1295 and Ipamorelin?
CJC-1295 and Ipamorelin act on different receptors and are most often researched in combination rather than as alternatives.
What is the half-life of CJC-1295 compared to Ipamorelin?
CJC-1295: ≈6–8 days with DAC; ≈30 minutes without DAC (Mod GRF 1-29). Ipamorelin: ≈2 hours.
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