Ipamorelin vs GHRP-6
Two ghrelin-mimetic GHRPs with very different selectivity profiles for appetite and cortisol.
In short: Ipamorelin is the more selective GHRP, with minimal effect on cortisol or hunger compared to GHRP-6.
Side-by-side comparison
| Ipamorelin | GHRP-6 | |
|---|---|---|
| Class / subtitle | Selective ghrelin-mimetic GHRP | Appetite-stimulating GH releasing peptide |
| Research status | In clinical trials | In clinical trials |
| Categories | Growth Hormone | Growth Hormone |
| Primary targets | GHS-R1a (ghrelin receptor) | GHS-R1a (ghrelin receptor) |
| Half-life | ≈2 hours | ≈15–60 minutes |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Molecular formula | C38H49N9O5 | C46H56N12O6 |
| Molecular weight | 711.85 g/mol | 873.01 g/mol |
| CAS number | 170851-70-4 | 87616-84-0 |
| Routes (research) | subcutaneous | subcutaneous |
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates GH release with minimal effect on cortisol, prolactin, or appetite, making it the cleanest of the classic GHRPs.
Full Ipamorelin profileGHRP-6 is one of the original growth hormone releasing peptides, notable for producing the strongest appetite stimulation of the GHRP family alongside its GH-releasing effect.
Full GHRP-6 profileFAQ
What is the main difference between Ipamorelin and GHRP-6?
Ipamorelin is the more selective GHRP, with minimal effect on cortisol or hunger compared to GHRP-6.
What is the half-life of Ipamorelin compared to GHRP-6?
Ipamorelin: ≈2 hours. GHRP-6: ≈15–60 minutes.
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