Ipamorelin vs Hexarelin
Selectivity versus potency: Hexarelin is among the strongest GHRPs but less clean than Ipamorelin.
In short: Hexarelin is more potent but associated with greater desensitisation and prolactin/cortisol effects than the highly selective Ipamorelin.
Side-by-side comparison
| Ipamorelin | Hexarelin | |
|---|---|---|
| Class / subtitle | Selective ghrelin-mimetic GHRP | Highly potent GHRP with cardiac research interest |
| Research status | In clinical trials | In clinical trials |
| Categories | Growth Hormone | Growth Hormone |
| Primary targets | GHS-R1a (ghrelin receptor) | GHS-R1a (ghrelin receptor), CD36 |
| Half-life | ≈2 hours | ≈55 minutes |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 | His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Molecular formula | C38H49N9O5 | C47H58N12O6 |
| Molecular weight | 711.85 g/mol | 887.04 g/mol |
| CAS number | 170851-70-4 | 140703-51-1 |
| Routes (research) | subcutaneous | subcutaneous |
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates GH release with minimal effect on cortisol, prolactin, or appetite, making it the cleanest of the classic GHRPs.
Full Ipamorelin profileHexarelin is among the most potent growth hormone releasing peptides and is distinguished by additional research interest in cardiac tissue via the CD36 receptor, though it is prone to receptor desensitisation.
Full Hexarelin profileFAQ
What is the main difference between Ipamorelin and Hexarelin?
Hexarelin is more potent but associated with greater desensitisation and prolactin/cortisol effects than the highly selective Ipamorelin.
What is the half-life of Ipamorelin compared to Hexarelin?
Ipamorelin: ≈2 hours. Hexarelin: ≈55 minutes.
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