Melanotan I
FDA-approvedMelanocortin Receptor Agonist
Synthetic analog of α-MSH that selectively targets MC1 receptors for melanin stimulation. FDA-approved as SCENESSE implant for erythropoietic protoporphyria (EPP).
Molecular & research data
- Sequence
- α-melanocyte stimulating hormone analog
- Molecular weight
- 1646.88 Da
- Half-life
- ~30 minutes
- Primary targets
- melanocortin-receptor
- Routes (research)
- Injectable, Nasal
- Storage
- Refrigerate reconstituted solution at 2-8°C, use within 4 weeks
Overview
Synthetic analog of α-MSH that selectively targets MC1 receptors for melanin stimulation. FDA-approved as SCENESSE implant for erythropoietic protoporphyria (EPP). Research-grade injectable form enables flexible dosing versus the implant version.
Mechanism of action
Subcutaneous injection delivers peptide directly into systemic circulation. Selectively activates MC1R receptors to stimulate melanin production. Short half-life of approximately 30 minutes necessitates multiple daily dosing for sustained effect.
Key research findings
- Precise dosing control with rapid tanning onset
- Flexible home administration unlike implant version
- Visible tanning within 1-2 weeks with UV exposure
- Enhanced photoprotection through increased melanin
- More selective for MC1R than Melanotan II
Research applications
Skin Health
- Enhanced Tanning Response — Stimulates melanin for deeper, longer-lasting tans with reduced UV requirements
- Photoprotection — Increased melanin density provides natural UV protection and reduces sunburn
- Even Pigmentation — Promotes uniform melanin distribution minimizing patchy tanning
Medical Applications
- Erythropoietic Protoporphyria — FDA-approved indication for SCENESSE implant
Melanotan I FAQ
Is Melanotan I more selective than Melanotan II?+
Yes. Melanotan I is more selective for MC1R (melanin production) and less active on MC4R (sexual function, appetite). This means MT-I causes tanning without the strong appetite suppression or sexual side effects of MT-II, making it better if tanning is the only goal.
How fast will I see results from Melanotan I?+
Initial skin darkening appears within 3-7 days with UV exposure. Peak tanning is visible by week 2-4 with consistent low-dose UV tanning. The combination of MT-I plus 50% less UV exposure than normal achieves deep tans much faster than sun exposure alone.
Can I use Melanotan I without any UV exposure?+
Melanotan I stimulates melanin production, so some pigment develops without sun exposure. However, UV exposure significantly enhances the effect—ideally low-dose tanning bed or sun exposure 1-2 hours after injection maximizes the tanning response.
Does Melanotan I cause mole changes like Melanotan II?+
Less commonly than MT-II, but moles and freckles can darken and potentially enlarge with MT-I use. Regular skin monitoring via self-examination is important. The risk appears lower with MT-I than MT-II due to reduced MC3R/MC4R activation.
References
Related peptides
Last reviewed: 2026-06-26. Information is provided for research and educational reference only — see our disclaimer.