AOD-9604
Bem estudadoModified hGH Fragment | Fat Loss Peptide
AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis and inhibits lipogenesis without the side effects of full growth hormone.
Dados moleculares e de pesquisa
- Sequência
- Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
- Peso molecular
- 1,815.1 Da
- Meia-vida
- 3-4 minutes
- Vias (pesquisa)
- injectable
- Armazenamento
- Lyophilized: room temp or freezer long-term. Reconstituted: 2-8°C for 28 days
Overview
AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis and inhibits lipogenesis without the side effects of full growth hormone. Unlike full GH, it does not increase IGF-1, affect glucose metabolism, or cause insulin resistance.
Mechanism of action
Stimulates lipolysis and inhibits lipogenesis through beta-3 adrenergic receptor upregulation, without binding to the GH receptor. Does not affect glucose metabolism or increase IGF-1 levels.
Key research findings
- Targets fat loss through selective lipolysis
- Avoids growth hormone side effects
- No effect on blood glucose or insulin
- Does not increase IGF-1 levels
- Metabolically safer than full hGH
- Emerging cartilage repair potential
Research applications
Fat Loss
- Lipolysis Enhancement — Increases fat oxidation, plasma glycerol levels, and reduces body weight in obese models without affecting glucose metabolism.
- Lipogenesis Inhibition — Reduces fat synthesis and storage in adipose tissue.
- Metabolic Safety — Does not cause hyperglycemia, reduce insulin secretion, or increase insulin resistance.
Joint Health
- Cartilage Repair — Enhanced cartilage regeneration when combined with hyaluronic acid in osteoarthritis models.
- Osteoarthritis Support — Synergistic effects with hyaluronic acid for joint health.
FAQ de AOD-9604
Does AOD-9604 cause blood sugar problems like full human growth hormone?+
No. AOD-9604 is a modified hGH fragment that stimulates lipolysis without binding to the GH receptor or affecting glucose metabolism. Unlike full GH which causes hyperglycemia and insulin resistance, AOD-9604 does not increase IGF-1 levels or disrupt glucose homeostasis, making it metabolically safer.
How quickly will I see fat loss with AOD-9604?+
Week 1-2 shows minimal noticeable effects as compound accumulates. Week 3-4 brings subtle body composition changes. Week 5-8 produces more noticeable fat loss especially with diet and exercise. Week 8-12 shows continued fat reduction and improved body composition. Total timeline is slower than GLP-1 agonists.
Can AOD-9604 be stacked with semaglutide or other weight loss peptides?+
Yes. AOD-9604's lipolytic mechanism complements semaglutide's appetite suppression through completely different pathways. However, combination data is limited. Both are safe separately; combining requires monitoring for additive dehydration/GI effects common with semaglutide.
Is there any cartilage repair evidence for AOD-9604 in humans?+
Animal studies show AOD-9604 combined with hyaluronic acid enhanced cartilage regeneration in osteoarthritis models. However, this is preclinical; human cartilage repair data doesn't exist. Joint health claims should be considered theoretical unless based on clinical trial data.
References
- [1]Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragmentInternational Journal of Obesity
- [2]The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out miceEndocrinology
- [3]Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolismAmerican Journal of Physiology - Endocrinology and Metabolism
- [4]Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormoneHormone Research
- [5]Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis ModelAnnals of Clinical and Laboratory Science
- [6]Detection and in vitro metabolism of AOD9604Drug Testing and Analysis
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HGH Fragment 176-191
Moderate researchGrowth Hormone Fragment | Fat Loss Peptide
HGH Fragment 176-191 is the fat-burning segment of human growth hormone, corresponding to amino acids 176 through 191 of the full GH molecule.