HGH

Overview

Human Growth Hormone (HGH/Somatropin) is a 191-amino acid polypeptide hormone FDA-approved for pediatric and adult growth hormone deficiency, HIV-associated wasting, and other conditions. It provides both direct and indirect (IGF-1 mediated) anabolic effects.

Mechanism of action

Binds to GH receptors on target tissues, triggering JAK2-STAT5 signaling pathway. Direct effects include lipolysis, protein synthesis, and metabolic regulation. Indirect effects via IGF-1 promote growth and anabolism. Half-life ~3 hours subcutaneously.

Key research findings

• Improved body composition (increased lean mass, decreased fat)
• Enhanced bone mineral density
• Improved lipid profile
• Increased exercise capacity
• Better quality of life and mood
• Skin, hair, and nail improvements
• Enhanced recovery and healing

Research applications

Growth Hormone Deficiency

• Pediatric GH Deficiency — FDA-approved for idiopathic and organic causes, Turner syndrome, Prader-Willi syndrome, SGA, Noonan syndrome, SHOX deficiency.
• Adult GH Deficiency — FDA-approved for childhood-onset or adult-onset causes (pituitary tumors, surgery, radiation, trauma).
• HIV-Associated Wasting — FDA-approved to increase lean body mass and body weight in cachexia.

Body Composition

• Fat Loss — Significant fat loss especially abdominal/visceral fat over 1-3 months.
• Lean Mass — Increased muscle mass and improved body composition.
• Recovery Enhancement — Enhanced exercise recovery and tissue healing.

Anti-Aging

• Skin and Hair Quality — Improved skin elasticity, texture, and hair/nail growth.
• Energy and Well-being — Improved energy, sleep, and quality of life.