IGF-1 LR3
Pesquisa limitadaModified Growth Factor Analog | Muscle Growth
IGF-1 LR3 is a synthetic 83-amino acid analog of insulin-like growth factor-1 that has never been approved for human use.
Dados moleculares e de pesquisa
- Meia-vida
- 20-30 hours
- Alvos primários
- igf1, mtor
- Vias (pesquisa)
- injectable
- Armazenamento
- Lyophilized: -20°C to -80°C. Reconstituted in acetic acid: 2-8°C for 1 year. Reconstituted in BAC water: use within 7 days
Overview
IGF-1 LR3 is a synthetic 83-amino acid analog of insulin-like growth factor-1 that has never been approved for human use. The N-terminal extension and R3 substitution reduce binding protein interaction, maintaining elevated free circulating levels with ~3x greater potency than native IGF-1.
Mechanism of action
Functions as a full IGF-1 receptor agonist activating PI3K/Akt/mTOR and MAPK/ERK pathways. The modifications prevent protein sequestration, maintaining elevated free circulating levels for extended anabolic effects.
Key research findings
- Approximately 3x more potent than native IGF-1
- Promotes muscle hypertrophy and hyperplasia in animal models
- 15-20% lean mass gains observed in 4-week rat studies
- Anti-catabolic effects preserve muscle during cachexia
- 20-30 hour half-life for sustained effects
Research applications
Muscle Growth
- Hypertrophy — 15-20% lean mass gains in 4 weeks through satellite cell activation (rat studies).
- Anti-Catabolic — Cancer cachexia rats maintained 30% more muscle versus placebo.
- Hyperplasia — Creates new muscle fibers via satellite cell differentiation.
Tissue Repair
- Wound Healing — Accelerated wound healing in animal models.
- Ligament/Tendon Recovery — Enhanced connective tissue repair.
Metabolic
- Nutrient Partitioning — Directs nutrients toward muscle tissue.
- Fat Loss — Enhanced lipolysis through IGF-1 pathway.
FAQ de IGF-1 LR3
Why is IGF-1 LR3 called 'long R3'?+
The N-terminal extension and R3 (arginine) substitution reduce binding to IGF binding proteins, allowing the peptide to circulate freely for 20-30 hours instead of being sequestered. This gives it approximately 3x greater potency and systemic presence than native IGF-1.
Can I take IGF-1 LR3 with HGH?+
Not recommended. Both are IGF-1 pathway agonists, and combining them creates excessive IGF-1 levels with amplified side effects including severe hypoglycemia, joint pain, organ enlargement risk, and carpal tunnel symptoms.
How long can I safely use IGF-1 LR3?+
Maximum recommended cycle is 4-6 weeks with equal off-time. Prolonged use risks receptor desensitization, excessive organ growth, and cumulative hypoglycemia danger. Most users run 4-6 week cycles with 4-6 weeks off between.
What happens if my blood sugar drops dangerously low on IGF-1 LR3?+
Severe hypoglycemia from IGF-1 LR3 can last 20-30 hours due to the long half-life. Consume 30-60g fast carbs immediately after injection and keep glucose tablets handy. Never inject before sleep. Consider having glucagon available for emergency hypoglycemia.
References
- [1]Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated ratsBiochemical Journal
- [2]Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated isletsAmerican Journal of Physiology - Regulatory, Integrative and Comparative Physiology
- [3]Insulin-like growth factor I preserves host lean tissue mass in cancer cachexiaAmerican Journal of Physiology
- [4]Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK BiobankCancer Research
- [5]Intranasal long R3 insulin-like growth factor-1 treatment promotes amyloid plaque remodeling in cerebral cortex but fails to preserve cognitive function in male 5XFAD miceAlzheimer's & Dementia
- [6]IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheepAmerican Journal of Physiology
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