PeptideDB

Cognitive peptides

Cognitive peptides are researched for effects on memory, focus, neuroprotection, and neuroplasticity. Many act on neurotrophic signalling or neurotransmitter systems and are studied in models of cognitive decline.

Adalank

Emerging research

N-Acetyl Selank Amidate | Enhanced Tuftsin Analog

Enhanced derivative of Selank with improved stability, blood-brain barrier penetration, and extended half-life compared to parent compound. Parent compound Selank approved in Russia since early 2000s.

CognitiveLongevity

Adamax

Emerging research

Next-Generation Semax Derivative | Nootropic Neuropeptide

Synthetic nootropic peptide with N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration, researched for cognitive enhancement,

CognitiveLongevity

Ara 290

Extensively studied

Tissue-Protective Peptide | Innate Repair Receptor Agonist

Ara 290 is an engineered 11-amino acid peptide activating the Innate Repair Receptor (IRR) to provide tissue-protective effects without red blood cell stimulation. Has FDA Orphan Drug status.

Recovery & HealingCognitive

Cerebrolysin

Well studied

Neuropeptide Preparation | Neurological Recovery

Standardized neuropeptide preparation containing bioactive peptides and amino acids exhibiting neurotrophic and neuroprotective properties for stroke recovery, traumatic brain injury, and cognitive

CognitiveLongevity

Cortagen

Moderate research

AEDP | Brain Cortex Bioregulator Peptide

Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St.

CognitiveLongevity

Cyclic Glycine-Proline

Moderate research

IGF-1 Bioavailability Regulator & Neuroprotective Peptide

Endogenous cyclic dipeptide found in plasma, breast milk, and cerebrospinal fluid. Functions as metabolite of IGF-1, regulating its bioavailability through competitive binding to IGFBP-3.

CognitiveLongevity

Dihexa

Emerging research

Synaptogenic Peptide | Cognitive Enhancement

Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis.

CognitiveLongevity

DNSP-11

Limited research

GDNF-Derived Peptide | Dopaminergic Neuroprotection

DNSP-11 is an 11-amino acid peptide derived from the pro-domain of glial cell line-derived neurotrophic factor (GDNF).

Cognitive

DSIP

Emerging research

Delta Sleep-Inducing Peptide | Sleep & Stress Modulator

DSIP is a naturally occurring nonapeptide discovered in 1974 in rabbit brain. Originally isolated for sleep-promoting properties, it has diverse neuromodulatory effects including stress reduction,

SleepCognitive

FGL

Limited research

NCAM-Derived Peptide | Synaptic Plasticity & Neuroprotection

FGL is a synthetic peptide derived from the second fibronectin type III module of neural cell adhesion molecule (NCAM).

Cognitive

Humanin

Moderate research

Mitochondria-Derived Peptide | HN

Humanin was the first mitochondria-derived peptide (MDP) discovered, originally cloned from the occipital lobe of an Alzheimer's patient.

LongevityCognitive

IllumiNeuro Protocol

Limited research

Four-Peptide Cognitive Enhancement Blend

IllumiNeuro is a cognitive enhancement peptide blend combining four nootropic peptides: PE-22-28 (neuritogenic), Pinealon (pineal bioregulator), NA-Semax Amidate (neuroprotective/cognitive), and

Cognitive

NA Semax Amidate

Well studied

Enhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection

Enhanced and stabilized version of Russian nootropic Semax with superior stability, extended half-life, and enhanced bioavailability through acetylation and amidation modifications.

CognitiveLongevity

NA-Selank Amidate

Moderate research

N-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic

NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics.

CognitiveLongevityImmune

Oxytocin

FDA-approved

Neurohypophysial Peptide | Social Bonding & Reproductive Hormone

Nine-amino-acid peptide hormone produced in hypothalamus, released by posterior pituitary. Functions in social bonding, trust, empathy, reproduction, childbirth, lactation.

HormonalCognitive

P21

Emerging research

P021 | CNTF-Derived Neurogenic Peptide

P21 is a nootropic peptide derived from ciliary neurotrophic factor (CNTF) that enhances neurogenesis and cognitive function.

CognitiveLongevity

PE-22-28

Emerging research

TREK-1 Channel Blocker | Shortened Spadin Analog

Synthetic heptapeptide derived from Spadin positions 22-28, functioning as potent TREK-1 antagonist with enhanced selectivity and duration versus parent compound.

CognitiveLongevity

Pinealon

Well studied

Synthetic Tripeptide | Neuroprotection & Cognitive Enhancement

Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement.

CognitiveSleepLongevity

Selank

Well studied

Anxiolytic & Nootropic Peptide | Tuftsin Analog

Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences.

CognitiveLongevityImmune

Semax

Well studied

Synthetic ACTH Analog | Nootropic & Neuroprotective Peptide

Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, originally developed in Russia for stroke recovery.

CognitiveLongevity

VIP

Extensively studied

Vasoactive Intestinal Peptide | Neuropeptide

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. It is produced in many tissues including the gut, pancreas, and brain.

ImmuneCognitive