Cognitive peptides
Cognitive peptides are researched for effects on memory, focus, neuroprotection, and neuroplasticity. Many act on neurotrophic signalling or neurotransmitter systems and are studied in models of cognitive decline.
Adalank
Emerging researchN-Acetyl Selank Amidate | Enhanced Tuftsin Analog
Enhanced derivative of Selank with improved stability, blood-brain barrier penetration, and extended half-life compared to parent compound. Parent compound Selank approved in Russia since early 2000s.
Adamax
Emerging researchNext-Generation Semax Derivative | Nootropic Neuropeptide
Synthetic nootropic peptide with N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration, researched for cognitive enhancement,
Ara 290
Extensively studiedTissue-Protective Peptide | Innate Repair Receptor Agonist
Ara 290 is an engineered 11-amino acid peptide activating the Innate Repair Receptor (IRR) to provide tissue-protective effects without red blood cell stimulation. Has FDA Orphan Drug status.
Cerebrolysin
Well studiedNeuropeptide Preparation | Neurological Recovery
Standardized neuropeptide preparation containing bioactive peptides and amino acids exhibiting neurotrophic and neuroprotective properties for stroke recovery, traumatic brain injury, and cognitive
Cortagen
Moderate researchAEDP | Brain Cortex Bioregulator Peptide
Cortagen is a Khavinson bioregulator tetrapeptide (AEDP) with primary effects on the brain and central nervous system. Developed at Russia's St.
Cyclic Glycine-Proline
Moderate researchIGF-1 Bioavailability Regulator & Neuroprotective Peptide
Endogenous cyclic dipeptide found in plasma, breast milk, and cerebrospinal fluid. Functions as metabolite of IGF-1, regulating its bioavailability through competitive binding to IGFBP-3.
Dihexa
Emerging researchSynaptogenic Peptide | Cognitive Enhancement
Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis.
DNSP-11
Limited researchGDNF-Derived Peptide | Dopaminergic Neuroprotection
DNSP-11 is an 11-amino acid peptide derived from the pro-domain of glial cell line-derived neurotrophic factor (GDNF).
DSIP
Emerging researchDelta Sleep-Inducing Peptide | Sleep & Stress Modulator
DSIP is a naturally occurring nonapeptide discovered in 1974 in rabbit brain. Originally isolated for sleep-promoting properties, it has diverse neuromodulatory effects including stress reduction,
FGL
Limited researchNCAM-Derived Peptide | Synaptic Plasticity & Neuroprotection
FGL is a synthetic peptide derived from the second fibronectin type III module of neural cell adhesion molecule (NCAM).
Humanin
Moderate researchMitochondria-Derived Peptide | HN
Humanin was the first mitochondria-derived peptide (MDP) discovered, originally cloned from the occipital lobe of an Alzheimer's patient.
IllumiNeuro Protocol
Limited researchFour-Peptide Cognitive Enhancement Blend
IllumiNeuro is a cognitive enhancement peptide blend combining four nootropic peptides: PE-22-28 (neuritogenic), Pinealon (pineal bioregulator), NA-Semax Amidate (neuroprotective/cognitive), and
NA Semax Amidate
Well studiedEnhanced Nootropic Peptide | Cognitive Enhancement & Neuroprotection
Enhanced and stabilized version of Russian nootropic Semax with superior stability, extended half-life, and enhanced bioavailability through acetylation and amidation modifications.
NA-Selank Amidate
Moderate researchN-Acetyl Selank Amidate | Enhanced Anxiolytic Nootropic
NA-Selank Amidate is an enhanced version of Selank, the anxiolytic nootropic peptide developed at Russia's Institute of Molecular Genetics.
Oxytocin
FDA-approvedNeurohypophysial Peptide | Social Bonding & Reproductive Hormone
Nine-amino-acid peptide hormone produced in hypothalamus, released by posterior pituitary. Functions in social bonding, trust, empathy, reproduction, childbirth, lactation.
P21
Emerging researchP021 | CNTF-Derived Neurogenic Peptide
P21 is a nootropic peptide derived from ciliary neurotrophic factor (CNTF) that enhances neurogenesis and cognitive function.
PE-22-28
Emerging researchTREK-1 Channel Blocker | Shortened Spadin Analog
Synthetic heptapeptide derived from Spadin positions 22-28, functioning as potent TREK-1 antagonist with enhanced selectivity and duration versus parent compound.
Pinealon
Well studiedSynthetic Tripeptide | Neuroprotection & Cognitive Enhancement
Developed in Russia, Pinealon demonstrates unique DNA-interaction for neuroprotection and cognitive enhancement.
Selank
Well studiedAnxiolytic & Nootropic Peptide | Tuftsin Analog
Selank is a synthetic heptapeptide analog of the naturally occurring immune peptide tuftsin, developed by the Russian Academy of Sciences.
Semax
Well studiedSynthetic ACTH Analog | Nootropic & Neuroprotective Peptide
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, originally developed in Russia for stroke recovery.
VIP
Extensively studiedVasoactive Intestinal Peptide | Neuropeptide
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. It is produced in many tissues including the gut, pancreas, and brain.