IllumiNeuro Protocol
Limited researchFour-Peptide Cognitive Enhancement Blend
IllumiNeuro is a cognitive enhancement peptide blend combining four nootropic peptides: PE-22-28 (neuritogenic), Pinealon (pineal bioregulator), NA-Semax Amidate (neuroprotective/cognitive), and
Molecular & research data
- Sequence
- PE-22-28 + Pinealon + NA-Semax + NA-Selank
- Primary targets
- bdnf, gaba
- Routes (research)
- Injectable, Nasal
- Storage
- Lyophilized: Room temperature. Reconstituted: 2-8°C, use within 4 weeks
Overview
IllumiNeuro is a cognitive enhancement peptide blend combining four nootropic peptides: PE-22-28 (neuritogenic), Pinealon (pineal bioregulator), NA-Semax Amidate (neuroprotective/cognitive), and NA-Selank Amidate (anxiolytic/cognitive). The standard formulation contains 48mg total (PE-22-28 10mg + Pinealon 10mg + NA-Semax 20mg + NA-Selank 8mg). This blend targets multiple neurological pathways for comprehensive cognitive support, though no clinical studies exist on this specific four-peptide combination.
Mechanism of action
Each peptide contributes distinct neurological mechanisms: PE-22-28 promotes neurite outgrowth and neural connectivity through sphingosine-1-phosphate receptor modulation; Pinealon is a bioregulator that supports pineal gland function and circadian regulation; NA-Semax Amidate provides BDNF upregulation and neuroprotection; NA-Selank Amidate offers anxiolytic effects through GABA modulation and immune-neuroendocrine regulation. Together, they theoretically address cognitive enhancement, neuroprotection, mood support, and neural regeneration.
Key research findings
- Multi-pathway cognitive enhancement
- Neuroprotective and neuritogenic effects
- Anxiolytic properties from NA-Selank
- BDNF upregulation from NA-Semax
- Circadian/sleep support from Pinealon
- Convenience of single injection
- Extended-action amidate forms included
Research applications
Cognitive Enhancement
- Memory & Learning — Combined BDNF support and neuritogenic effects may enhance memory formation and learning.
- Focus & Concentration — NA-Semax component supports sustained attention and mental clarity.
- Neuroprotection — Multiple pathways protecting neural tissue from oxidative stress and damage.
Mood & Anxiety
- Anxiety Reduction — NA-Selank provides anxiolytic effects through GABA modulation.
- Stress Adaptation — Immune-neuroendocrine support helps with stress resilience.
- Mood Support — Combined effects on neurotransmitter systems may improve overall mood.
Neural Health
- Neurite Outgrowth — PE-22-28 promotes neural connectivity and neurite extension.
- Circadian Regulation — Pinealon supports healthy sleep-wake cycles and pineal function.
IllumiNeuro Protocol FAQ
What's in IllumiNeuro and why is it a blend?+
IllumiNeuro combines four neuroactive peptides: PE-22-28 (neurite growth), Pinealon (pineal/circadian support), NA-Semax (BDNF/neuroprotection), and NA-Selank (anxiety relief). The blend targets multiple cognitive pathways simultaneously for theoretically broader benefits than any single peptide.
Can I take IllumiNeuro separately or must I use the blend?+
You can take individual components separately, but do NOT add extra NA-Semax or NA-Selank to the blend—they're already included. The standard 48mg vial contains all four at fixed ratios: PE-22-28 10mg, Pinealon 10mg, NA-Semax 20mg, NA-Selank 8mg.
Does IllumiNeuro work for anxiety specifically?+
The NA-Selank component has documented anxiolytic effects via GABA modulation. However, no clinical studies exist on this four-peptide combination. Individual peptides show promise for anxiety in research, but human efficacy data is limited.
Should I inject IllumiNeuro in the morning or evening?+
Morning dosing is preferred for cognitive benefits during the day. Pinealon's sleep-supporting properties might suggest evening, but most users report better focus and mental clarity when dosed in the morning on an empty stomach.
References
Related peptides
Epitalon
PreclinicalTetrapeptide studied for telomere & pineal effects
Epitalon is a synthetic tetrapeptide derived from the pineal peptide epithalamin, studied primarily in Russian research for proposed effects on telomerase activity, circadian regulation, and ageing.
Dihexa
Emerging researchSynaptogenic Peptide | Cognitive Enhancement
Dihexa is a synthetic oligopeptide derived from angiotensin IV that potently enhances cognitive function by promoting synaptogenesis.
BPC-157
PreclinicalPentadecapeptide studied for tissue repair
BPC-157 is a synthetic 15-amino-acid peptide derived from a protein found in gastric juice, studied extensively in animal models for accelerated healing of tendon, ligament, muscle, and gut tissue.
Last reviewed: 2026-06-26. Information is provided for research and educational reference only — see our disclaimer.