PeptideDB

Metabolic peptides

Metabolic peptides are investigated for their effects on insulin sensitivity, glucose regulation, mitochondrial function, and overall energy metabolism — often overlapping with the weight-loss and longevity categories.

5-Amino-1MQ

Preclinical

NNMT Inhibitor | Longevity & Metabolic Enhancement

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function.

LongevityMetabolicWeight Loss

AICAR

Limited research

5-Aminoimidazole-4-carboxamide Ribonucleotide | AMPK Activator

AICAR is a cell-permeable nucleoside analog that activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis.

MetabolicPerformance

AOD-9604

Well studied

Modified hGH Fragment | Fat Loss Peptide

AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis and inhibits lipogenesis without the side effects of full growth hormone.

Weight LossMetabolic

BAM-15

Moderate research

Mitochondrial Uncoupler | Metabolic Enhancer

BAM-15 is a synthetic mitochondrial uncoupler that has emerged as a promising research compound for obesity and metabolic disorders.

Weight LossMetabolic

Cagrilintide

Extensively studied

Long-Acting Amylin Receptor Agonist | Weight Loss & Diabetes

Novel long-acting lipidated amylin analog functioning as dual amylin and calcitonin receptor agonist for weight management and type 2 diabetes.

Weight LossMetabolic

Erythropoietin (EPO)

Extensively studied

EPO | Red Blood Cell Stimulating Hormone

Erythropoietin (EPO) is an essential glycoprotein hormone that stimulates red blood cell production.

Metabolic

HGH Fragment 176-191

Moderate research

Growth Hormone Fragment | Fat Loss Peptide

HGH Fragment 176-191 is the fat-burning segment of human growth hormone, corresponding to amino acids 176 through 191 of the full GH molecule.

Weight LossMetabolic

KLOW Protocol

Limited research

Four-Peptide Regenerative Blend

KLOW builds upon GLOW protocol by adding KPV for enhanced anti-inflammatory action.

Weight LossMetabolic

L-Carnitine

Established

Amino Acid Derivative | Fatty Acid Transporter

L-Carnitine is an amino acid derivative naturally produced in the body and essential for transporting long-chain fatty acids into mitochondria for energy production.

MetabolicPerformance

Mazdutide

Extensively studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

First-in-class dual GLP-1 and glucagon receptor agonist combining appetite suppression with thermogenesis stimulation.

Weight LossMetabolic

NAD+

Extensively studied

Essential Cellular Coenzyme & Anti-Aging Therapy

NAD+ is a crucial coenzyme found in every cell, involved in energy generation and cellular maintenance that naturally declines with age.

LongevityMetabolic

Orforglipron

Extensively studied

Oral Small-Molecule GLP-1 Receptor Agonist | Weight Loss & Diabetes

First oral non-peptide GLP-1 completing Phase 3 trials. Achieves substantial weight loss without injections, refrigeration, or dietary restrictions, with clinical evidence of 12.4% weight reduction

Weight LossMetabolic

Pancragen

Moderate research

KEDW Tetrapeptide | Pancreas Bioregulator

Pancragen is a Khavinson bioregulator tetrapeptide (KEDW) originally isolated from bovine pancreatic cells. Developed at Russia's St.

LongevityMetabolic

Retatrutide

Extensively studied

Triple GLP-1/GIP/Glucagon Agonist | Weight Loss & Diabetes

Novel triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors. Phase II trials demonstrated 24.2% weight loss at 48 weeks—the highest recorded for obesity medications.

Weight LossMetabolic

SLU-PP-332

Emerging research

Synthetic Pan-ERR Agonist | Exercise Mimetic & Metabolic Modulator

Groundbreaking synthetic compound from Saint Louis University functioning as pan-estrogen-related receptor agonist with preferential ERRα activity.

MetabolicLongevity

SS-31

Well studied

Mitochondrial-Targeted Peptide | Cardiolipin Protector

SS-31 (Elamipretide) is an aromatic-cationic tetrapeptide that selectively binds to cardiolipin in the inner mitochondrial membrane, preventing lipid peroxidation and optimizing electron transport

LongevityMetabolic

Survodutide

Extensively studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

Investigational dual receptor agonist targeting metabolic disease through balanced GLP-1R and GCGR activation. Phase 2/3 clinical trials demonstrate superior weight loss and MASH treatment efficacy.

Weight LossMetabolic