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AOD-9604

Well studied

Modified hGH Fragment | Fat Loss Peptide

Weight LossMetabolic

AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis and inhibits lipogenesis without the side effects of full growth hormone.

Molecular & research data

Sequence
Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Molecular weight
1,815.1 Da
Half-life
3-4 minutes
Routes (research)
Injectable
Storage
Lyophilized: room temp or freezer long-term. Reconstituted: 2-8°C for 28 days

Overview

AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis and inhibits lipogenesis without the side effects of full growth hormone. Unlike full GH, it does not increase IGF-1, affect glucose metabolism, or cause insulin resistance.

Mechanism of action

Stimulates lipolysis and inhibits lipogenesis through beta-3 adrenergic receptor upregulation, without binding to the GH receptor. Does not affect glucose metabolism or increase IGF-1 levels.

Key research findings

  • Targets fat loss through selective lipolysis
  • Avoids growth hormone side effects
  • No effect on blood glucose or insulin
  • Does not increase IGF-1 levels
  • Metabolically safer than full hGH
  • Emerging cartilage repair potential

Research applications

Fat Loss

  • Lipolysis Enhancement — Increases fat oxidation, plasma glycerol levels, and reduces body weight in obese models without affecting glucose metabolism.
  • Lipogenesis Inhibition — Reduces fat synthesis and storage in adipose tissue.
  • Metabolic Safety — Does not cause hyperglycemia, reduce insulin secretion, or increase insulin resistance.

Joint Health

  • Cartilage Repair — Enhanced cartilage regeneration when combined with hyaluronic acid in osteoarthritis models.
  • Osteoarthritis Support — Synergistic effects with hyaluronic acid for joint health.

AOD-9604 FAQ

Does AOD-9604 cause blood sugar problems like full human growth hormone?+

No. AOD-9604 is a modified hGH fragment that stimulates lipolysis without binding to the GH receptor or affecting glucose metabolism. Unlike full GH which causes hyperglycemia and insulin resistance, AOD-9604 does not increase IGF-1 levels or disrupt glucose homeostasis, making it metabolically safer.

How quickly will I see fat loss with AOD-9604?+

Week 1-2 shows minimal noticeable effects as compound accumulates. Week 3-4 brings subtle body composition changes. Week 5-8 produces more noticeable fat loss especially with diet and exercise. Week 8-12 shows continued fat reduction and improved body composition. Total timeline is slower than GLP-1 agonists.

Can AOD-9604 be stacked with semaglutide or other weight loss peptides?+

Yes. AOD-9604's lipolytic mechanism complements semaglutide's appetite suppression through completely different pathways. However, combination data is limited. Both are safe separately; combining requires monitoring for additive dehydration/GI effects common with semaglutide.

Is there any cartilage repair evidence for AOD-9604 in humans?+

Animal studies show AOD-9604 combined with hyaluronic acid enhanced cartilage regeneration in osteoarthritis models. However, this is preclinical; human cartilage repair data doesn't exist. Joint health claims should be considered theoretical unless based on clinical trial data.

References

  1. [1]Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragmentInternational Journal of Obesity
  2. [2]The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out miceEndocrinology
  3. [3]Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolismAmerican Journal of Physiology - Endocrinology and Metabolism
  4. [4]Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormoneHormone Research
  5. [5]Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis ModelAnnals of Clinical and Laboratory Science
  6. [6]Detection and in vitro metabolism of AOD9604Drug Testing and Analysis

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Last reviewed: 2026-06-26. Information is provided for research and educational reference only — see our disclaimer.