Weight Loss peptides
Weight-loss peptides span incretin mimetics (GLP-1 and dual GLP-1/GIP agonists), growth-hormone fragments, and other appetite- and lipolysis-modulating compounds. This is one of the fastest-moving areas of peptide research.
5-Amino-1MQ
PreclinicalNNMT Inhibitor | Longevity & Metabolic Enhancement
5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function.
Adipotide
Emerging researchProhibitin-Targeting Peptidomimetic | Experimental Anti-Obesity
Chimeric adipose-vasculature-targeted peptidomimetic targeting prohibitin/annexin A2 on white adipose tissue endothelium, delivering pro-apoptotic D-(KLAKLAK)2 motif.
AOD-9604
Well studiedModified hGH Fragment | Fat Loss Peptide
AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis and inhibits lipogenesis without the side effects of full growth hormone.
BAM-15
Moderate researchMitochondrial Uncoupler | Metabolic Enhancer
BAM-15 is a synthetic mitochondrial uncoupler that has emerged as a promising research compound for obesity and metabolic disorders.
Cagrilintide
Extensively studiedLong-Acting Amylin Receptor Agonist | Weight Loss & Diabetes
Novel long-acting lipidated amylin analog functioning as dual amylin and calcitonin receptor agonist for weight management and type 2 diabetes.
CJC-1295 with DAC
Well studiedLong-Acting Growth Hormone Releasing Hormone Analog | Extended Release
Modified growth hormone releasing hormone engineered for extended duration via albumin-binding technology. DAC binds to albumin, extending half-life and providing continuous GHRH receptor stimulation.
CJC/IPA Protocol
Well studiedGHRH/GHRP Combination | Growth Hormone Optimization
A dual-pathway protocol combining CJC-1295 and Ipamorelin that targets growth hormone secretion through complementary mechanisms.
HGH
FDA-approvedHuman Growth Hormone | Somatropin
Human Growth Hormone (HGH/Somatropin) is a 191-amino acid polypeptide hormone FDA-approved for pediatric and adult growth hormone deficiency, HIV-associated wasting, and other conditions.
HGH Fragment 176-191
Moderate researchGrowth Hormone Fragment | Fat Loss Peptide
HGH Fragment 176-191 is the fat-burning segment of human growth hormone, corresponding to amino acids 176 through 191 of the full GH molecule.
KLOW Protocol
Limited researchFour-Peptide Regenerative Blend
KLOW builds upon GLOW protocol by adding KPV for enhanced anti-inflammatory action.
Mazdutide
Extensively studiedDual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes
First-in-class dual GLP-1 and glucagon receptor agonist combining appetite suppression with thermogenesis stimulation.
MK-677
Well studiedGhrelin Receptor Agonist | Oral Growth Hormone Secretagogue
Oral compound activating ghrelin receptors to trigger growth hormone release while preserving natural production.
MOTS-c
PreclinicalMitochondrial-derived peptide studied for metabolism
MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial DNA, studied in animal models for its role in metabolic regulation, insulin sensitivity, and exercise-like adaptations.
Orforglipron
Extensively studiedOral Small-Molecule GLP-1 Receptor Agonist | Weight Loss & Diabetes
First oral non-peptide GLP-1 completing Phase 3 trials. Achieves substantial weight loss without injections, refrigeration, or dietary restrictions, with clinical evidence of 12.4% weight reduction
Retatrutide
Extensively studiedTriple GLP-1/GIP/Glucagon Agonist | Weight Loss & Diabetes
Novel triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors. Phase II trials demonstrated 24.2% weight loss at 48 weeks—the highest recorded for obesity medications.
Semaglutide
FDA-approvedFDA-approved GLP-1 receptor agonist
Semaglutide is an FDA-approved GLP-1 receptor agonist for type 2 diabetes and chronic weight management, engineered with fatty-acid acylation for a once-weekly half-life.
Survodutide
Extensively studiedDual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes
Investigational dual receptor agonist targeting metabolic disease through balanced GLP-1R and GCGR activation. Phase 2/3 clinical trials demonstrate superior weight loss and MASH treatment efficacy.
Tesamorelin
FDA-approvedFDA-approved stabilised GHRH analog
Tesamorelin is a stabilised GHRH analog and the only growth-hormone secretagogue with FDA approval specifically for reducing excess visceral fat (in HIV-associated lipodystrophy).
Tirzepatide
FDA-approvedFDA-approved dual GIP/GLP-1 receptor agonist
Tirzepatide is an FDA-approved dual GIP and GLP-1 receptor agonist for type 2 diabetes and weight management, producing larger average weight reduction than GLP-1-only agents in trials.