PeptideDB

Weight Loss peptides

Weight-loss peptides span incretin mimetics (GLP-1 and dual GLP-1/GIP agonists), growth-hormone fragments, and other appetite- and lipolysis-modulating compounds. This is one of the fastest-moving areas of peptide research.

5-Amino-1MQ

Preclinical

NNMT Inhibitor | Longevity & Metabolic Enhancement

5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function.

LongevityMetabolicWeight Loss

Adipotide

Emerging research

Prohibitin-Targeting Peptidomimetic | Experimental Anti-Obesity

Chimeric adipose-vasculature-targeted peptidomimetic targeting prohibitin/annexin A2 on white adipose tissue endothelium, delivering pro-apoptotic D-(KLAKLAK)2 motif.

Weight Loss

AOD-9604

Well studied

Modified hGH Fragment | Fat Loss Peptide

AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191) that stimulates lipolysis and inhibits lipogenesis without the side effects of full growth hormone.

Weight LossMetabolic

BAM-15

Moderate research

Mitochondrial Uncoupler | Metabolic Enhancer

BAM-15 is a synthetic mitochondrial uncoupler that has emerged as a promising research compound for obesity and metabolic disorders.

Weight LossMetabolic

Cagrilintide

Extensively studied

Long-Acting Amylin Receptor Agonist | Weight Loss & Diabetes

Novel long-acting lipidated amylin analog functioning as dual amylin and calcitonin receptor agonist for weight management and type 2 diabetes.

Weight LossMetabolic

CJC-1295 with DAC

Well studied

Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release

Modified growth hormone releasing hormone engineered for extended duration via albumin-binding technology. DAC binds to albumin, extending half-life and providing continuous GHRH receptor stimulation.

Growth HormoneWeight Loss

CJC/IPA Protocol

Well studied

GHRH/GHRP Combination | Growth Hormone Optimization

A dual-pathway protocol combining CJC-1295 and Ipamorelin that targets growth hormone secretion through complementary mechanisms.

Growth HormoneWeight Loss

HGH

FDA-approved

Human Growth Hormone | Somatropin

Human Growth Hormone (HGH/Somatropin) is a 191-amino acid polypeptide hormone FDA-approved for pediatric and adult growth hormone deficiency, HIV-associated wasting, and other conditions.

Growth HormoneWeight LossRecovery & Healing

HGH Fragment 176-191

Moderate research

Growth Hormone Fragment | Fat Loss Peptide

HGH Fragment 176-191 is the fat-burning segment of human growth hormone, corresponding to amino acids 176 through 191 of the full GH molecule.

Weight LossMetabolic

KLOW Protocol

Limited research

Four-Peptide Regenerative Blend

KLOW builds upon GLOW protocol by adding KPV for enhanced anti-inflammatory action.

Weight LossMetabolic

Mazdutide

Extensively studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

First-in-class dual GLP-1 and glucagon receptor agonist combining appetite suppression with thermogenesis stimulation.

Weight LossMetabolic

MK-677

Well studied

Ghrelin Receptor Agonist | Oral Growth Hormone Secretagogue

Oral compound activating ghrelin receptors to trigger growth hormone release while preserving natural production.

Growth HormoneWeight LossSleep

MOTS-c

Preclinical

Mitochondrial-derived peptide studied for metabolism

MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial DNA, studied in animal models for its role in metabolic regulation, insulin sensitivity, and exercise-like adaptations.

LongevityWeight Loss

Orforglipron

Extensively studied

Oral Small-Molecule GLP-1 Receptor Agonist | Weight Loss & Diabetes

First oral non-peptide GLP-1 completing Phase 3 trials. Achieves substantial weight loss without injections, refrigeration, or dietary restrictions, with clinical evidence of 12.4% weight reduction

Weight LossMetabolic

Retatrutide

Extensively studied

Triple GLP-1/GIP/Glucagon Agonist | Weight Loss & Diabetes

Novel triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors. Phase II trials demonstrated 24.2% weight loss at 48 weeks—the highest recorded for obesity medications.

Weight LossMetabolic

Semaglutide

FDA-approved

FDA-approved GLP-1 receptor agonist

Semaglutide is an FDA-approved GLP-1 receptor agonist for type 2 diabetes and chronic weight management, engineered with fatty-acid acylation for a once-weekly half-life.

Weight Loss

Survodutide

Extensively studied

Dual GLP-1/Glucagon Receptor Agonist | Weight Loss & Diabetes

Investigational dual receptor agonist targeting metabolic disease through balanced GLP-1R and GCGR activation. Phase 2/3 clinical trials demonstrate superior weight loss and MASH treatment efficacy.

Weight LossMetabolic

Tesamorelin

FDA-approved

FDA-approved stabilised GHRH analog

Tesamorelin is a stabilised GHRH analog and the only growth-hormone secretagogue with FDA approval specifically for reducing excess visceral fat (in HIV-associated lipodystrophy).

Growth HormoneWeight Loss

Tirzepatide

FDA-approved

FDA-approved dual GIP/GLP-1 receptor agonist

Tirzepatide is an FDA-approved dual GIP and GLP-1 receptor agonist for type 2 diabetes and weight management, producing larger average weight reduction than GLP-1-only agents in trials.

Weight Loss