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CJC-1295 with DAC

Well studied

Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release

Growth HormoneWeight Loss

Modified growth hormone releasing hormone engineered for extended duration via albumin-binding technology. DAC binds to albumin, extending half-life and providing continuous GHRH receptor stimulation.

Molecular & research data

Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys
Molecular weight
3,647.28 Da
Half-life
6-8 days
Primary targets
ghrh-receptor, igf1
Routes (research)
Injectable
Storage
Lyophilized: 2-8°C refrigerated; Reconstituted: 2-8°C refrigerated, use within 30 days

Overview

Modified growth hormone releasing hormone engineered for extended duration via albumin-binding technology. DAC binds to albumin, extending half-life and providing continuous GHRH receptor stimulation.

Mechanism of action

DAC binds to albumin, extending half-life to 6-8 days and providing continuous GHRH receptor stimulation for sustained GH/IGF-1 elevation.

Key research findings

  • Convenient weekly dosing
  • Sustained GH/IGF-1 elevation
  • 6-8 day half-life
  • Significant body composition changes

Research applications

Growth Hormone

  • Sustained GH Elevation — Continuous growth hormone release for 6-8 days per injection.
  • IGF-1 Optimization — Significantly elevates IGF-1 levels for extended periods.
  • Convenience Protocol — Weekly dosing ideal for simple administration.

Body Composition

  • Fat Loss Enhancement — Continuous GH elevation promotes lipolysis and fat metabolism.
  • Lean Mass Gains — Sustained anabolic environment supports muscle protein synthesis.

Anti-Aging

  • Recovery Enhancement — Accelerated healing and recovery from exercise or injury.

CJC-1295 with DAC FAQ

How much more expensive is CJC-1295 with DAC compared to without DAC?+

CJC-1295 with DAC typically costs 2-3x more than the non-DAC version due to complex albumin-binding manufacturing. The higher cost reflects the DAC technology enabling weekly dosing versus daily injections required for the basic version, making weekly administration more convenient despite the price premium.

Is CJC-1295 with DAC safe to combine with testosterone therapy?+

CJC-1295 with DAC can be used with testosterone but requires careful monitoring. Combining continuous GH elevation with exogenous testosterone increases risk of joint pain, water retention, and elevated IGF-1 beyond safe levels. Most protocols separate them or use lower doses of each when combined.

Why does some people report joint pain during CJC-1295 DAC use?+

Joint pain and carpal tunnel symptoms occur due to sustained GH and IGF-1 elevation causing water retention in joints and connective tissues. Unlike pulsatile protocols where GH spikes then drops, the 6-8 day DAC half-life creates continuous elevation that may stress joints, particularly in high-dose users.

Can you switch between CJC-1295 with DAC and without DAC during a cycle?+

Switching between variants mid-cycle is not recommended because they have different pharmacokinetics—DAC provides sustained elevation while non-DAC creates pulsatile release. Combining them risks excessive GH levels and unpredictable effects. Choose one variant at the start and maintain consistency throughout your cycle.

References

  1. [1]Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy AdultsJournal of Clinical Endocrinology & Metabolism
  2. [2]Pulsatile Secretion of Growth Hormone (GH) Persists During Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone AnalogJournal of Clinical Endocrinology & Metabolism
  3. [3]Human Growth Hormone-Releasing Factor (hGRF)1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF AnalogEndocrinology
  4. [4]Activation of the GH/IGF-1 Axis by CJC-1295, a Long-Acting GHRH Analog, Results in Serum Protein Profile Changes in Normal Adult SubjectsGrowth Hormone & IGF Research
  5. [5]Growth Hormone-Releasing Hormone and Its Analogues in Health and DiseaseEndocrine Reviews

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Last reviewed: 2026-06-26. Information is provided for research and educational reference only — see our disclaimer.