Growth Hormone peptides
Growth hormone secretagogues fall into two mechanistic families: GHRH analogs that act on the pituitary GHRH receptor, and ghrelin-mimetic GHRPs that act on the GHS-R1a receptor. Researchers often study them together because the two pathways are synergistic.
ACE-031
Emerging researchMyostatin Inhibitor | Experimental Muscle Growth
ACE-031 is a soluble form of the activin type IIB receptor (ActRIIB) fused to an IgG1 Fc domain.
CJC-1295
In clinical trialsLong-acting GHRH analog
CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH) engineered for a dramatically extended half-life, studied for its ability to raise growth hormone and IGF-1 levels.
CJC-1295 with DAC
Well studiedLong-Acting Growth Hormone Releasing Hormone Analog | Extended Release
Modified growth hormone releasing hormone engineered for extended duration via albumin-binding technology. DAC binds to albumin, extending half-life and providing continuous GHRH receptor stimulation.
CJC/IPA Protocol
Well studiedGHRH/GHRP Combination | Growth Hormone Optimization
A dual-pathway protocol combining CJC-1295 and Ipamorelin that targets growth hormone secretion through complementary mechanisms.
GHRP-2
In clinical trialsPotent ghrelin-mimetic GH secretagogue
GHRP-2 (pralmorelin) is a potent growth hormone releasing peptide used clinically as a diagnostic agent in some countries, known for strong GH release with moderate appetite and cortisol effects.
GHRP-6
In clinical trialsAppetite-stimulating GH releasing peptide
GHRP-6 is one of the original growth hormone releasing peptides, notable for producing the strongest appetite stimulation of the GHRP family alongside its GH-releasing effect.
Hexarelin
In clinical trialsHighly potent GHRP with cardiac research interest
Hexarelin is among the most potent growth hormone releasing peptides and is distinguished by additional research interest in cardiac tissue via the CD36 receptor, though it is prone to receptor desensitisation.
HGH
FDA-approvedHuman Growth Hormone | Somatropin
Human Growth Hormone (HGH/Somatropin) is a 191-amino acid polypeptide hormone FDA-approved for pediatric and adult growth hormone deficiency, HIV-associated wasting, and other conditions.
IGF-1 DES
Limited researchTruncated IGF-1 Analog | Localized Muscle Growth
IGF-1 DES (Des(1-3) IGF-1) is a truncated analog of insulin-like growth factor-1, missing the first three N-terminal amino acids.
IGF-1 LR3
Limited researchModified Growth Factor Analog | Muscle Growth
IGF-1 LR3 is a synthetic 83-amino acid analog of insulin-like growth factor-1 that has never been approved for human use.
Ipamorelin
In clinical trialsSelective ghrelin-mimetic GHRP
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates GH release with minimal effect on cortisol, prolactin, or appetite, making it the cleanest of the classic GHRPs.
MGF
Limited researchMechano Growth Factor | IGF-1 Splice Variant
Non-pegylated IGF-1 splice variant produced locally in muscle tissue following mechanical stress.
MK-677
Well studiedGhrelin Receptor Agonist | Oral Growth Hormone Secretagogue
Oral compound activating ghrelin receptors to trigger growth hormone release while preserving natural production.
PEG-MGF
Limited researchPegylated Mechano Growth Factor | IGF-1 Splice Variant
Modified IGF-1 variant with PEG attachment extending half-life from minutes to hours. Activates muscle satellite cells following mechanical stress or injury.
Sermorelin
FDA-approvedShort-acting GHRH(1-29) analog
Sermorelin is a GHRH analog made of the first 29 amino acids of growth-hormone-releasing hormone — the shortest fragment that retains full activity. It was FDA-approved for diagnostic and therapeutic use before being commercially discontinued.
Tesa/IPA Protocol
Limited researchTesamorelin + Ipamorelin GH Secretagogue Blend
The Tesa/IPA blend combines two complementary growth hormone secretagogues: Tesamorelin (a GHRH analog that stimulates GH release from the pituitary) and Ipamorelin (a selective ghrelin mimetic/GHRP
Tesamorelin
FDA-approvedFDA-approved stabilised GHRH analog
Tesamorelin is a stabilised GHRH analog and the only growth-hormone secretagogue with FDA approval specifically for reducing excess visceral fat (in HIV-associated lipodystrophy).