PeptideDB

Growth Hormone peptides

Growth hormone secretagogues fall into two mechanistic families: GHRH analogs that act on the pituitary GHRH receptor, and ghrelin-mimetic GHRPs that act on the GHS-R1a receptor. Researchers often study them together because the two pathways are synergistic.

ACE-031

Emerging research

Myostatin Inhibitor | Experimental Muscle Growth

ACE-031 is a soluble form of the activin type IIB receptor (ActRIIB) fused to an IgG1 Fc domain.

Growth HormoneAnabolic

CJC-1295

In clinical trials

Long-acting GHRH analog

CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH) engineered for a dramatically extended half-life, studied for its ability to raise growth hormone and IGF-1 levels.

Growth Hormone

CJC-1295 with DAC

Well studied

Long-Acting Growth Hormone Releasing Hormone Analog | Extended Release

Modified growth hormone releasing hormone engineered for extended duration via albumin-binding technology. DAC binds to albumin, extending half-life and providing continuous GHRH receptor stimulation.

Growth HormoneWeight Loss

CJC/IPA Protocol

Well studied

GHRH/GHRP Combination | Growth Hormone Optimization

A dual-pathway protocol combining CJC-1295 and Ipamorelin that targets growth hormone secretion through complementary mechanisms.

Growth HormoneWeight Loss

GHRP-2

In clinical trials

Potent ghrelin-mimetic GH secretagogue

GHRP-2 (pralmorelin) is a potent growth hormone releasing peptide used clinically as a diagnostic agent in some countries, known for strong GH release with moderate appetite and cortisol effects.

Growth Hormone

GHRP-6

In clinical trials

Appetite-stimulating GH releasing peptide

GHRP-6 is one of the original growth hormone releasing peptides, notable for producing the strongest appetite stimulation of the GHRP family alongside its GH-releasing effect.

Growth Hormone

Hexarelin

In clinical trials

Highly potent GHRP with cardiac research interest

Hexarelin is among the most potent growth hormone releasing peptides and is distinguished by additional research interest in cardiac tissue via the CD36 receptor, though it is prone to receptor desensitisation.

Growth Hormone

HGH

FDA-approved

Human Growth Hormone | Somatropin

Human Growth Hormone (HGH/Somatropin) is a 191-amino acid polypeptide hormone FDA-approved for pediatric and adult growth hormone deficiency, HIV-associated wasting, and other conditions.

Growth HormoneWeight LossRecovery & Healing

IGF-1 DES

Limited research

Truncated IGF-1 Analog | Localized Muscle Growth

IGF-1 DES (Des(1-3) IGF-1) is a truncated analog of insulin-like growth factor-1, missing the first three N-terminal amino acids.

Growth Hormone

IGF-1 LR3

Limited research

Modified Growth Factor Analog | Muscle Growth

IGF-1 LR3 is a synthetic 83-amino acid analog of insulin-like growth factor-1 that has never been approved for human use.

Growth HormoneRecovery & Healing

Ipamorelin

In clinical trials

Selective ghrelin-mimetic GHRP

Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates GH release with minimal effect on cortisol, prolactin, or appetite, making it the cleanest of the classic GHRPs.

Growth Hormone

MGF

Limited research

Mechano Growth Factor | IGF-1 Splice Variant

Non-pegylated IGF-1 splice variant produced locally in muscle tissue following mechanical stress.

Growth HormoneRecovery & Healing

MK-677

Well studied

Ghrelin Receptor Agonist | Oral Growth Hormone Secretagogue

Oral compound activating ghrelin receptors to trigger growth hormone release while preserving natural production.

Growth HormoneWeight LossSleep

PEG-MGF

Limited research

Pegylated Mechano Growth Factor | IGF-1 Splice Variant

Modified IGF-1 variant with PEG attachment extending half-life from minutes to hours. Activates muscle satellite cells following mechanical stress or injury.

Growth HormoneRecovery & Healing

Sermorelin

FDA-approved

Short-acting GHRH(1-29) analog

Sermorelin is a GHRH analog made of the first 29 amino acids of growth-hormone-releasing hormone — the shortest fragment that retains full activity. It was FDA-approved for diagnostic and therapeutic use before being commercially discontinued.

Growth Hormone

Tesa/IPA Protocol

Limited research

Tesamorelin + Ipamorelin GH Secretagogue Blend

The Tesa/IPA blend combines two complementary growth hormone secretagogues: Tesamorelin (a GHRH analog that stimulates GH release from the pituitary) and Ipamorelin (a selective ghrelin mimetic/GHRP

Growth Hormone

Tesamorelin

FDA-approved

FDA-approved stabilised GHRH analog

Tesamorelin is a stabilised GHRH analog and the only growth-hormone secretagogue with FDA approval specifically for reducing excess visceral fat (in HIV-associated lipodystrophy).

Growth HormoneWeight Loss