GHRP-2
In clinical trialsPotent ghrelin-mimetic GH secretagogue
Also known as: Pralmorelin, KP-102, GHRP-2
GHRP-2 (pralmorelin) is a potent growth hormone releasing peptide used clinically as a diagnostic agent in some countries, known for strong GH release with moderate appetite and cortisol effects.
Molecular & research data
- Sequence
- D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
- CAS number
- 158861-67-7
- Molecular formula
- C45H55N9O6
- Molecular weight
- 817.96 g/mol
- Half-life
- ≈15–60 minutes
- Primary targets
- GHS-R1a (ghrelin receptor)
- Routes (research)
- Subcutaneous
- Storage
- Lyophilised: −20 °C. Reconstituted: 2–8 °C, use within weeks.
Overview
GHRP-2, also known as pralmorelin, is a synthetic hexapeptide in the growth hormone releasing peptide family. It is one of the more potent GHRPs and, unusually for compounds in this space, has a genuine clinical role as a diagnostic agent for growth hormone secretion in some countries.
Mechanism of action
GHRP-2 binds the GHS-R1a (ghrelin) receptor on the pituitary, driving a strong pulse of growth hormone release. As a ghrelin mimetic it also stimulates appetite, and at higher doses can produce modest increases in cortisol and prolactin — effects that are stronger in GHRP-6 and largely absent in the selective Ipamorelin.
Because it works on the ghrelin pathway, GHRP-2 is synergistic with GHRH analogs and is often studied in combination with them.
Common research uses
- Diagnostic testing of pituitary GH reserve
- Research into appetite and GH regulation
- As a potency benchmark in comparisons across the GHRP family
Compare GHRP-2
GHRP-2 FAQ
What is GHRP-2 used for clinically?+
In some countries (notably Japan) pralmorelin is used as a diagnostic agent to test growth hormone secretory capacity.
How does GHRP-2 compare to GHRP-6?+
GHRP-2 is generally the more potent GH releaser, while GHRP-6 produces the strongest hunger response. GHRP-2 still stimulates appetite and can modestly raise cortisol and prolactin, but less than GHRP-6.
Is GHRP-2 the same as Ipamorelin?+
No. Both act on the ghrelin receptor, but Ipamorelin is far more selective, with minimal cortisol, prolactin, or appetite effects compared with GHRP-2.
References
Related peptides
GHRP-6
In clinical trialsAppetite-stimulating GH releasing peptide
GHRP-6 is one of the original growth hormone releasing peptides, notable for producing the strongest appetite stimulation of the GHRP family alongside its GH-releasing effect.
Ipamorelin
In clinical trialsSelective ghrelin-mimetic GHRP
Ipamorelin is a selective growth hormone releasing peptide (GHRP) that stimulates GH release with minimal effect on cortisol, prolactin, or appetite, making it the cleanest of the classic GHRPs.
Hexarelin
In clinical trialsHighly potent GHRP with cardiac research interest
Hexarelin is among the most potent growth hormone releasing peptides and is distinguished by additional research interest in cardiac tissue via the CD36 receptor, though it is prone to receptor desensitisation.
Last reviewed: 2026-06-26. Information is provided for research and educational reference only — see our disclaimer.