GHRP-2 vs GHRP-6
The two classic GHRPs, compared on potency, appetite stimulation, and cortisol.
In short: GHRP-2 is generally the more potent GH releaser; GHRP-6 produces the strongest hunger response of the GHRP family.
Side-by-side comparison
| GHRP-2 | GHRP-6 | |
|---|---|---|
| Class / subtitle | Potent ghrelin-mimetic GH secretagogue | Appetite-stimulating GH releasing peptide |
| Research status | In clinical trials | In clinical trials |
| Categories | Growth Hormone | Growth Hormone |
| Primary targets | GHS-R1a (ghrelin receptor) | GHS-R1a (ghrelin receptor) |
| Half-life | ≈15–60 minutes | ≈15–60 minutes |
| Sequence | D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2 | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Molecular formula | C45H55N9O6 | C46H56N12O6 |
| Molecular weight | 817.96 g/mol | 873.01 g/mol |
| CAS number | 158861-67-7 | 87616-84-0 |
| Routes (research) | subcutaneous | subcutaneous |
GHRP-2 (pralmorelin) is a potent growth hormone releasing peptide used clinically as a diagnostic agent in some countries, known for strong GH release with moderate appetite and cortisol effects.
Full GHRP-2 profileGHRP-6 is one of the original growth hormone releasing peptides, notable for producing the strongest appetite stimulation of the GHRP family alongside its GH-releasing effect.
Full GHRP-6 profileFAQ
What is the main difference between GHRP-2 and GHRP-6?
GHRP-2 is generally the more potent GH releaser; GHRP-6 produces the strongest hunger response of the GHRP family.
What is the half-life of GHRP-2 compared to GHRP-6?
GHRP-2: ≈15–60 minutes. GHRP-6: ≈15–60 minutes.
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